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INTEGRIN ALPHA-IIB BETA-3
Descriptors Found:
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DeCS
Descriptor
English
:
Platelet Glycoprotein GPIIb-IIIa Complex
Descriptor
Spanish
:
Complejo GPIIb-IIIa de Glicoproteína Plaquetaria
Descriptor
Portuguese
:
Complexo Glicoproteico GPIIb-IIIa de Plaquetas
Synonyms
English
:
Glycoproteins IIb-IIIa
Integrin alpha-IIb beta-3
GPIIb IIIa Receptors
Glycoproteins IIb IIIa
Integrin alpha IIb beta 3
Platelet Glycoprotein GPIIb IIIa Complex
Receptors, GPIIb-IIIa
alphaIIbbeta3, Integrin
beta-3, Integrin alpha-IIb
GPIIb-IIIa Receptors
Integrin alphaIIbbeta3
Tree Number:
D12.776.395.550.625.785
D12.776.543.550.625.785
D12.776.543.750.705.408.460.700
D12.776.543.750.705.675.784
Definition
English
:
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and
INTEGRIN BETA3
which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive
proteins
. As such, it is a receptor for
FIBRINOGEN
;
VON WILLEBRAND FACTOR
; FIBRONECTIN;
VITRONECTIN
; and
THROMBOSPONDINS
. A deficiency of GPIIb-IIIa results in GLANZMANN
THROMBASTHENIA.
Entry Combination - descr/qualif
English
:
Platelet Glycoprotein GPIIb-IIIa Complex
/
deficiency
use
Thrombasthenia
See Related
English
:
Thrombasthenia
History Note
English
:
1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
32647
Unique Identifier:
D019039
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS